Title: Anti-neuroinflammatory Effects of the Extract of Achillea Fragrantissima

Anti-Neuroinflammatory effects of the extract of Achillea fragrantissima

BACKGROUND The neuroinflammatory process plays a central role in the initiation and progression of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases, and involves the activation of brain microglial cells. During the neuroinflammatory process, microglial cells release proinflammatory mediators such as cytokines, matrix metalloproteinases (MMP), Reactive oxygen species (ROS)...

Anti-inflammatory and Cyclooxygenases Inhibitory Effects of Asteraceae, Rich in Flavonoids and Tannins

The species of Asteraceae were used traditionally in treatment of inflammatory disorders. The present study aimed to assess the anti-inflammatory effect of methanolic extract of aerial parts of Rhanterium epapposum Oliv. (R.epapposum), Achillea fragrantissima (Forssk.) Sch.Bip (A. fragrantissima), Artemisia herba-alba Asso. (A.herba-alba), Echinops spinosus L. (E. spinosus) and Echinops hussoni...

Extract of Achillea fragrantissima Downregulates ROS Production and Protects Astrocytes from Oxidative-Stress-Induced Cell Death

New Insights into Antioxidant and Antiviral Activities of Two Wild Medicinal Plants: Achillea Fragrantissima and Nitraria Retusa

The present work was undertaken to evaluate the polyphenolic content, antioxidant and antiviral properties of two wild medicinal plants; Achillea fragrantissima and Nitraria retusa. The crude extracts of both plants were prepared using methanol and ethyl acetate solvents. Generally, total phenolic content ranged from 0.31 to 15.05 mg gallic acid equivalents /g dw, where total flavonoid content ...

Downregulation of microglial activation by achillolide A.

Chronic inflammation has been implicated in the pathogenesis of various neurodegenerative diseases. During the neuroinflammatory process, microglial cells release neurotoxic and proinflammatory mediators. In the present study, using activity-guided fractionation, we have purified an anti-inflammatory compound determined by spectroscopic methods to be a sesquiterpene lactone named achillolide A ...